{"_id":"5d5551a0084aa9001127aa1d","project":"5b0e13ffc4664e0003c75a66","version":{"_id":"5b0e13ffc4664e0003c75a67","project":"5b0e13ffc4664e0003c75a66","__v":4,"createdAt":"2015-09-17T16:58:03.490Z","releaseDate":"2015-09-17T16:58:03.490Z","categories":["5b0e13ffc4664e0003c75a68","5b0e13ffc4664e0003c75a69","5b0e13ffc4664e0003c75a6a","5b0e13ffc4664e0003c75a6b","5b0e13ffc4664e0003c75a6c","5b0e13ffc4664e0003c75a6d","5b0e13ffc4664e0003c75a6e","5b0e13ffc4664e0003c75a6f","5b0e13ffc4664e0003c75a70","5b0e13ffc4664e0003c75a71","5b0e13ffc4664e0003c75a72","5b0e13ffc4664e0003c75a73","5b0e13ffc4664e0003c75a74","5b0e13ffc4664e0003c75a75","5b0e13ffc4664e0003c75a76","5b0e13ffc4664e0003c75a77","5b0e13ffc4664e0003c75a89","5b0e13ffc4664e0003c75a8a","5b0e13ffc4664e0003c75a9d","5b0e13ffc4664e0003c75a9e","5b0e13ffc4664e0003c75a9f","5b0e13ffc4664e0003c75aa0","5b0e13ffc4664e0003c75aa1","5b0e13ffc4664e0003c75aa2","5b0e13ffc4664e0003c75aa3","5b0e13ffc4664e0003c75aa4","5b0e13ffc4664e0003c75aa5","5b0e13ffc4664e0003c75aa6","5b0e13ffc4664e0003c75aa7","5b0e13ffc4664e0003c75aa8","5b0e13ffc4664e0003c75aa9","5b0e13ffc4664e0003c75aaa","5b0e13ffc4664e0003c75aab","5b0e13ffc4664e0003c75aac","5b0e13ffc4664e0003c75aad","5b0e13ffc4664e0003c75aae","5b0e13ffc4664e0003c75aaf","5b0e13ffc4664e0003c75ab2","5bb3374f4306ad0003eb18e7","5bbf3c5373e72a000318362b","5bc065567d1cb0000384c649","5cbf19a5f9181f0033fbb968"],"is_deprecated":false,"is_hidden":false,"is_beta":true,"is_stable":true,"codename":"","version_clean":"1.0.0","version":"1.0"},"category":{"_id":"5b0e13ffc4664e0003c75aaa","project":"5b0e13ffc4664e0003c75a66","version":"5b0e13ffc4664e0003c75a67","__v":0,"sync":{"url":"","isSync":false},"reference":false,"createdAt":"2016-12-05T15:44:15.650Z","from_sync":false,"order":6,"slug":"datasets-hub","title":"DATASETS HUB"},"user":"566590c83889610d0008a253","__v":0,"parentDoc":null,"metadata":{"title":"","description":"","image":[]},"updates":[],"next":{"pages":[],"description":""},"createdAt":"2019-08-15T12:35:44.795Z","link_external":false,"link_url":"","sync_unique":"","hidden":false,"api":{"results":{"codes":[]},"settings":"","auth":"required","params":[],"url":""},"isReference":false,"order":26,"body":"## Description\n\nThe description below was taken directly from the NCBI database of Genotypes and Phenotypes ([dbGaP](https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000946)):\n\nChronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States and the only leading cause of death that is steadily increasing in frequency.\n\nThis project collected a set of extended pedigrees ascertained through subjects with severe, early-onset COPD. This study has enrolled subjects with severe COPD (forced expiratory volume in one second (FEV1) < 40% predicted) at an early age (< 53 years) without alpha-1 antitrypsin deficiency (a known Mendelian risk factor for COPD).\n\nExtended pedigrees are enrolled, primarily in New England, although some more geographically distant subjects have been included. This study has been used for epidemiological studies, familial aggregation analysis, linkage analysis, and candidate gene association analysis.\n\nApproximately 80 of the severe, early-onset COPD probands will undergo whole genome sequencing in this project with sequencing data available through dbGaP.\n\n##General information\n[block:parameters]\n{\n  \"data\": {\n    \"h-0\": \"phs#\",\n    \"h-1\": \"Study abbreviation\",\n    \"h-2\": \"Study type\",\n    \"0-1\": \"EOCOPD\",\n    \"0-2\": \"Pedigree Whole Genome Sequencing\",\n    \"0-0\": \"phs000946\",\n    \"h-3\": \"TOPMed project\",\n    \"0-3\": \"COPD\",\n    \"h-4\": \"Parent phs#\",\n    \"0-4\": \"phs000286\",\n    \"h-5\": \"Keywords\",\n    \"0-5\": \"EOCOPD; phs000946; Lung; Pedigree; Pulmonary disease; Family; WGS;\"\n  },\n  \"cols\": 5,\n  \"rows\": 1\n}\n[/block]","excerpt":"","slug":"boston-early-onset-copd-study","type":"basic","title":"phs000946 Boston Early-Onset COPD Study"}

phs000946 Boston Early-Onset COPD Study


## Description The description below was taken directly from the NCBI database of Genotypes and Phenotypes ([dbGaP](https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000946)): Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States and the only leading cause of death that is steadily increasing in frequency. This project collected a set of extended pedigrees ascertained through subjects with severe, early-onset COPD. This study has enrolled subjects with severe COPD (forced expiratory volume in one second (FEV1) < 40% predicted) at an early age (< 53 years) without alpha-1 antitrypsin deficiency (a known Mendelian risk factor for COPD). Extended pedigrees are enrolled, primarily in New England, although some more geographically distant subjects have been included. This study has been used for epidemiological studies, familial aggregation analysis, linkage analysis, and candidate gene association analysis. Approximately 80 of the severe, early-onset COPD probands will undergo whole genome sequencing in this project with sequencing data available through dbGaP. ##General information [block:parameters] { "data": { "h-0": "phs#", "h-1": "Study abbreviation", "h-2": "Study type", "0-1": "EOCOPD", "0-2": "Pedigree Whole Genome Sequencing", "0-0": "phs000946", "h-3": "TOPMed project", "0-3": "COPD", "h-4": "Parent phs#", "0-4": "phs000286", "h-5": "Keywords", "0-5": "EOCOPD; phs000946; Lung; Pedigree; Pulmonary disease; Family; WGS;" }, "cols": 5, "rows": 1 } [/block]