{"_id":"5d5405c23b90a600686d0d9a","project":"5b0e13ffc4664e0003c75a66","version":{"_id":"5b0e13ffc4664e0003c75a67","project":"5b0e13ffc4664e0003c75a66","__v":4,"createdAt":"2015-09-17T16:58:03.490Z","releaseDate":"2015-09-17T16:58:03.490Z","categories":["5b0e13ffc4664e0003c75a68","5b0e13ffc4664e0003c75a69","5b0e13ffc4664e0003c75a6a","5b0e13ffc4664e0003c75a6b","5b0e13ffc4664e0003c75a6c","5b0e13ffc4664e0003c75a6d","5b0e13ffc4664e0003c75a6e","5b0e13ffc4664e0003c75a6f","5b0e13ffc4664e0003c75a70","5b0e13ffc4664e0003c75a71","5b0e13ffc4664e0003c75a72","5b0e13ffc4664e0003c75a73","5b0e13ffc4664e0003c75a74","5b0e13ffc4664e0003c75a75","5b0e13ffc4664e0003c75a76","5b0e13ffc4664e0003c75a77","5b0e13ffc4664e0003c75a89","5b0e13ffc4664e0003c75a8a","5b0e13ffc4664e0003c75a9d","5b0e13ffc4664e0003c75a9e","5b0e13ffc4664e0003c75a9f","5b0e13ffc4664e0003c75aa0","5b0e13ffc4664e0003c75aa1","5b0e13ffc4664e0003c75aa2","5b0e13ffc4664e0003c75aa3","5b0e13ffc4664e0003c75aa4","5b0e13ffc4664e0003c75aa5","5b0e13ffc4664e0003c75aa6","5b0e13ffc4664e0003c75aa7","5b0e13ffc4664e0003c75aa8","5b0e13ffc4664e0003c75aa9","5b0e13ffc4664e0003c75aaa","5b0e13ffc4664e0003c75aab","5b0e13ffc4664e0003c75aac","5b0e13ffc4664e0003c75aad","5b0e13ffc4664e0003c75aae","5b0e13ffc4664e0003c75aaf","5b0e13ffc4664e0003c75ab2","5bb3374f4306ad0003eb18e7","5bbf3c5373e72a000318362b","5bc065567d1cb0000384c649","5cbf19a5f9181f0033fbb968"],"is_deprecated":false,"is_hidden":false,"is_beta":true,"is_stable":true,"codename":"","version_clean":"1.0.0","version":"1.0"},"category":{"_id":"5b0e13ffc4664e0003c75aaa","project":"5b0e13ffc4664e0003c75a66","version":"5b0e13ffc4664e0003c75a67","__v":0,"sync":{"url":"","isSync":false},"reference":false,"createdAt":"2016-12-05T15:44:15.650Z","from_sync":false,"order":6,"slug":"datasets-hub","title":"DATASETS HUB"},"user":"566590c83889610d0008a253","__v":0,"parentDoc":null,"metadata":{"title":"","description":"","image":[]},"updates":[],"next":{"pages":[],"description":""},"createdAt":"2019-08-14T12:59:46.092Z","link_external":false,"link_url":"","sync_unique":"","hidden":false,"api":{"settings":"","results":{"codes":[]},"auth":"required","params":[],"url":""},"isReference":false,"order":5,"body":"## Description\n\nThe description below was taken directly from the NCBI database of Genotypes and Phenotypes ([dbGaP](https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001416)):\n\nThe Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the characteristics of subclinical cardiovascular disease (disease detected non-invasively before it has produced clinical signs and symptoms) and the risk factors that predict progression to clinically overt cardiovascular disease or progression of the subclinical disease. MESA researchers study a diverse, population-based sample of 6,814 asymptomatic men and women aged 45-84. Thirty-eight percent of the recruited participants are white, 28 percent African-American, 22 percent Hispanic, and 12 percent Asian, predominantly of Chinese descent.\n\nParticipants were recruited from six field centers across the United States: Wake Forest University, Columbia University, Johns Hopkins University, University of Minnesota, Northwestern University and University of California - Los Angeles. Each participant received an extensive physical exam and determination of coronary calcification, ventricular mass and function, flow-mediated endothelial vasodilation, carotid intimal-medial wall thickness and presence of echogenic lucencies in the carotid artery, lower extremity vascular insufficiency, arterial wave forms, electrocardiographic (ECG) measures, standard coronary risk factors, sociodemographic factors, lifestyle factors, and psychosocial factors. Selected repetition of subclinical disease measures and risk factors at follow-up visits allows study of the progression of disease. Blood samples have been assayed for putative biochemical risk factors and stored for case-control studies. DNA has been extracted and lymphocytes cryopreserved (for possible immortalization) for study of candidate genes and possibly, genome-wide scanning, expression, and other genetic techniques. Participants are being followed for identification and characterization of cardiovascular disease events, including acute myocardial infarction and other forms of coronary heart disease (CHD), stroke, and congestive heart failure; for cardiovascular disease interventions; and for mortality... ([phs000209](https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000209.v13.p3))\n\n\n##General information\n[block:parameters]\n{\n  \"data\": {\n    \"h-0\": \"phs#\",\n    \"h-1\": \"Study abbreviation\",\n    \"h-2\": \"Study type\",\n    \"0-1\": \"MESA\",\n    \"0-2\": \"Longitudinal, Family\",\n    \"0-0\": \"phs001416\",\n    \"h-3\": \"TOPMed project\",\n    \"0-3\": \"MESA\",\n    \"h-4\": \"Parent phs#\",\n    \"0-4\": \"phs000209\",\n    \"h-5\": \"Keywords\",\n    \"0-5\": \"MESA; phs001416; Heart; Cardiovascular; Multi-Ethnic; Longitudinal; Family; WGS;\"\n  },\n  \"cols\": 5,\n  \"rows\": 1\n}\n[/block]","excerpt":"","slug":"mesa-and-mesa-family-aa-cac","type":"basic","title":"phs001416 MESA and MESA Family AA-CAC"}

phs001416 MESA and MESA Family AA-CAC


## Description The description below was taken directly from the NCBI database of Genotypes and Phenotypes ([dbGaP](https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001416)): The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the characteristics of subclinical cardiovascular disease (disease detected non-invasively before it has produced clinical signs and symptoms) and the risk factors that predict progression to clinically overt cardiovascular disease or progression of the subclinical disease. MESA researchers study a diverse, population-based sample of 6,814 asymptomatic men and women aged 45-84. Thirty-eight percent of the recruited participants are white, 28 percent African-American, 22 percent Hispanic, and 12 percent Asian, predominantly of Chinese descent. Participants were recruited from six field centers across the United States: Wake Forest University, Columbia University, Johns Hopkins University, University of Minnesota, Northwestern University and University of California - Los Angeles. Each participant received an extensive physical exam and determination of coronary calcification, ventricular mass and function, flow-mediated endothelial vasodilation, carotid intimal-medial wall thickness and presence of echogenic lucencies in the carotid artery, lower extremity vascular insufficiency, arterial wave forms, electrocardiographic (ECG) measures, standard coronary risk factors, sociodemographic factors, lifestyle factors, and psychosocial factors. Selected repetition of subclinical disease measures and risk factors at follow-up visits allows study of the progression of disease. Blood samples have been assayed for putative biochemical risk factors and stored for case-control studies. DNA has been extracted and lymphocytes cryopreserved (for possible immortalization) for study of candidate genes and possibly, genome-wide scanning, expression, and other genetic techniques. Participants are being followed for identification and characterization of cardiovascular disease events, including acute myocardial infarction and other forms of coronary heart disease (CHD), stroke, and congestive heart failure; for cardiovascular disease interventions; and for mortality... ([phs000209](https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000209.v13.p3)) ##General information [block:parameters] { "data": { "h-0": "phs#", "h-1": "Study abbreviation", "h-2": "Study type", "0-1": "MESA", "0-2": "Longitudinal, Family", "0-0": "phs001416", "h-3": "TOPMed project", "0-3": "MESA", "h-4": "Parent phs#", "0-4": "phs000209", "h-5": "Keywords", "0-5": "MESA; phs001416; Heart; Cardiovascular; Multi-Ethnic; Longitudinal; Family; WGS;" }, "cols": 5, "rows": 1 } [/block]